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    Planta Med. 1983 Jul;48(7):136-41.

    Chemistry, 13C-NMR Study and Pharmacology of Two Saponins from Colubrina asiatica.

    Wagner H, Ott S, Jurcic K, Morton J, Neszmelyi A.

    Source

    Institut für Pharmazeutische Biologie der Universität München.

    Abstract

    From the leaves of COLUBRINA ASIATICA B RONGEN (Rhamnaceae) two saponins have been isolated and structurally elucidated, mainly by (13)C-NMR-spectroscopic methods, as jujubogenin-3-O-[2-O-acetyl-3-O-(3-O-beta-D-xylopyranosyl-4-O-acetyl-beta-D-glucopyranosyl)-alpha-L-arabinoside] (colubrinoside) and jujubogenin-3-O- [2-O-acetyl -3-O- (2-O- beta -D- xylopyranosyl-beta-D-glucopyranosyl)-alpha-L-arabinoside] (colubrin) respectively. Both saponins inhibit the spontaneous motility of mice, even at low doses (1 mg/ kg), they show an antagonistic effect on amphetamine and exert a synergistic activity on chlordiazepoxide.

    PMID:
    17404972
    [PubMed - in process]

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