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Schizophr Bull. 2007 May;33(3):789-91. Epub 2007 Apr 2.

Anti-Toxoplasma gondii antibodies in patients with schizophrenia--preliminary findings in a Turkish sample.

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  • 1Department of Microbiology, Faculty of Medicine, Afyon Kocatepe University, Afyon, Turkey.


Schizophrenia is a serious neuropsychiatric disease of uncertain etiology. We investigated the seropositivity rate for anti-Toxoplasma IgG and IgM antibodies by enzyme-linked immunosorbent assay (ELISA) in patients with schizophrenia to ascertain a possible relationship between Toxoplasma gondii and schizophrenia. We selected 100 patients with schizophrenia, 50 with depressive disorder, and 50 healthy volunteers to investigate the seropositivity rate of anti-Toxoplasma antibodies by ELISA. The seropositivity rate for anti-Toxoplasma IgG antibodies among schizophrenia patients (66%) was significantly higher than among patients with depressive disorder or healthy volunteers (P < .01). Thus, there might be a causal relationship between toxoplasmosis and the etiology of schizophrenia.

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