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Phytochemistry. 2007 Jul;68(14):1882-903. Epub 2007 Apr 2.

Natural products with calmodulin inhibitor properties.

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  • 1Departamento de Farmacia, Facultad de Química, Universidad Nacional Autónoma de México, DF 04510, Mexico.


This review summarizes properties of various naturally occurring compounds with reported calmodulin (CaM)-inhibitory properties which include about 159 natural products belonging to different structural classes. Most inhibitors are alkaloid and peptide type of compounds and have been isolated from a wide variety of natural sources, including many plant species. Among the most potent natural anti-CaM substances, however, are several animal venoms and the antibiotic polymixin. The largest number of compounds described were discovered by means of enzymatic functional assays.

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