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Biochem Biophys Res Commun. 2007 May 18;356(4):976-80. Epub 2007 Mar 26.

Inhibitory effects of caffeine on hippocampal neurogenesis and function.

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  • 1Department of Anatomy, School of Medicine, Pusan National University, 1-10 Ami-Dong, Seo-Gu, Pusan 602-739, Republic of Korea.


Caffeine is one of the most extensively consumed psychostimulants in the world. However, compared to short-term effects of caffeine, the long-term effects of caffeine consumption on learning and memory are poorly characterized. The present study found that long-term consumption of low dose caffeine (0.3 g/L) slowed hippocampus-dependent learning and impaired long-term memory. Caffeine consumption for 4 weeks also significantly reduced hippocampal neurogenesis compared to controls. From these results, we concluded that long-term consumption of caffeine could inhibit hippocampus-dependent learning and memory partially through inhibition of hippocampal neurogenesis.

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