Reprod Toxicol. 2007 Jun;23(4):611-3. Epub 2007 Feb 25.

Favorable pregnancy outcome following Trastuzumab (Herceptin) use during pregnancy--Case report and updated literature review.

Shrim A, Garcia-Bournissen F, Maxwell C, Farine D, Koren G.

Source

The Motherisk Program, Division of Clinical Pharmacology/Toxicology, Hospital for Sick Children, University of Toronto, Ontario, Canada. alon.shrim@gmail.com

Abstract

BACKGROUND: Trastuzumab (Herceptin) is a monoclonal antibody used for the treatment of breast cancer. Experience with use of this agent during pregnancy, and its possible effects on the fetus, is limited. CASE: We present a case of a patient with breast cancer who was treated with trastuzumab during the first 24 weeks of pregnancy. This treatment was associated with reversible maternal heart failure, which resolved slowly after the drug was discontinued, but with no adverse fetal effects and a normal infant examination at the age of 2 months. Updated literature review is discussed.

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Reprod Toxicol. 2008 Apr;25(3):390-1; author reply 392.

PMID:: 17399946; [PubMed - indexed for MEDLINE]

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