Biochim Biophys Acta. 1992 Jan 23;1115(3):187-91.

Effect of oxygen tension and lactate concentration on keratan sulphate and chondroitin sulphate biosynthesis in bovine cornea.

Balduini C, De Luca G, Passi A, Rindi S, Salvini R, Scott JE.

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Department of Biochemistry, University of Pavia, Italy.

Abstract

Calf cornea slices were incubated with [U-14C]glucose, in varying pO2 or lactate concentrations. Acid glycosaminoglycans were separated by ion-exchange chromatography after papain digestion. The percentage radioactivity incorporated into keratan sulphate increased markedly with decreased oxygen tension, whereas a concomitant relative decrease of the biosynthesis of glycosaminoglycuronans occurred. Similar results were obtained with increased lactate concentration. Our findings support the idea that keratan sulphate is a functional substitute for chondroitin sulphate in conditions of oxygen lack (Scott, J.E. and Haigh, M. (1988) J. Anat. 158, 95-108).

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Differential effect of oxygen supply and lactate concentration on keratan sulphate and glycosaminoglycuronan production in bovine cornea. [Biochem Soc Trans. 1991]
Differential effect of oxygen supply and lactate concentration on keratan sulphate and glycosaminoglycuronan production in bovine cornea.
Balduini C, De Luca G, Passi A, Rindi S, Salvini R, Scott JE. Biochem Soc Trans. 1991 Nov; 19(4):354S.
Keratan sulphate: a functional substitute for chondroitin sulphate in O2 deficient tissues? [Pathol Biol (Paris). 1989]
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Review [Sulfotransferases involved in the biosynthesis of glycosaminoglycans].
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Effect of oxygen tension and lactate concentration on keratan sulphate and chondroitin sulphate biosynthesis in bovine cornea.

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