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Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 Apr;103(4):e35-41. Epub 2006 Sep 12.

Central giant cell granuloma associated with central ossifying fibroma of the jaws: a clinicopathologic study.

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  • 1Pathology Service, Rabin Medical Center, Beilinson Campus.

Abstract

OBJECTIVE:

To investigate the prevalence of clinical, radiographic, and histopathologic characteristics of combined central giant cell granuloma (CGCG) and central ossifying fibroma (COF).

STUDY DESIGN:

Retrospective clinical and histomorphometric analysis of all cases diagnosed as CGCG or COF between 1994 and 2002.

RESULTS:

A total of 51 cases were included in the study: CGCG (n = 23), COF (n = 25), and combined COF-CGCG (n = 3). All 3 lesions presented expansile, well-defined unilocular radiolucencies, with radiopacities (66%), root resorption (66%) and tooth displacement (33%). Microscopically, areas of classical CGCG and COF were separated by a transition zone of nonvascularized densely packed spindle cells. Surgical procedure resulted in recurrence within 1 year in 1 of 2 patients, calcitonin nasal spray treatment resulted in growth arrest in 1 case.

CONCLUSIONS:

Because of the small number of the combined cases, the biologic behavior of the lesions is uncertain. The CGCG component may drive the clinical behavior toward a more aggressive behavior than classical COF; therefore, close follow-up is recommended.

PMID:
17395058
[PubMed - indexed for MEDLINE]
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