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Sci STKE. 2007 Mar 27;2007(379):pe11.

Unconventional roles of the NADPH oxidase: signaling, ion homeostasis, and cell death.

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  • 1Program in Cell Biology, Hospital for Sick Children, Toronto, Canada.


Although the central role of the phagocytic NADPH oxidase in mediating bacterial killing has long been appreciated, this sophisticated enzyme complex serves various other important functions. This Perspective focuses on these underappreciated roles of phagocytic NADPH oxidase, highlighting recent work implicating reactive oxygen species in triggering an unconventional form of cell death.

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