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Mol Endocrinol. 2007 Jun;21(6):1267-80. Epub 2007 Mar 27.

The macrophage migration inhibitory factor-glucocorticoid dyad: regulation of inflammation and immunity.

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  • 1Yale University School of Medicine, New Haven, Connecticut 06520, USA.


The cytokine macrophage migration inhibitory factor (MIF) occupies a unique position in physiology by its ability to directly regulate the immunosuppressive actions of glucocorticoids. We review herein the interactions between MIF and glucocorticoids within the immune system and discuss the relevance of the MIF-glucocorticoid regulatory dyad in physiology and immunopathology. Therapeutic antagonism of MIF may be an effective approach for steroid-sparing therapies in patients with refractory autoimmune or inflammatory diseases.

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