Mol Cell. 2007 Mar 23;25(6):933-42.

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.

Kvansakul M, van Delft MF, Lee EF, Gulbis JM, Fairlie WD, Huang DC, Colman PM.

Source

The Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Victoria 3050, Australia.

Abstract

Many viruses express antiapoptotic proteins to counter host defense mechanisms that would otherwise trigger the rapid clearance of infected cells. For example, adenoviruses and some gamma-herpesviruses express homologs of prosurvival Bcl-2 to subvert the host's apoptotic machinery. Myxoma virus, a double-stranded DNA virus of the pox family, harbors antiapoptotic M11L, its virulence factor. Analysis of its three-dimensional structure reveals that despite lacking any primary sequence similarity to Bcl-2, it adopts a virtually identical protein fold. This allows it to associate with BH3 domains, especially those of Bax and Bak. We found that M11L acts primarily by sequestering Bax and Bak, thereby blocking the killing action of these essential cell-death mediators. These findings expand the family of protein sequences that act like Bcl-2 to block apoptosis and support the conclusion that the prosurvival action of these proteins critically depends on their ability to bind and antagonize Bax and/or Bak.

PMID:: 17386268; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2. [Protein Sci. 2007]
Structure of M11L: A myxoma virus structural homolog of the apoptosis inhibitor, Bcl-2.
Douglas AE, Corbett KD, Berger JM, McFadden G, Handel TM. Protein Sci. 2007 Apr; 16(4):695-703.
Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak. [J Virol. 2004]
Myxoma virus M11L prevents apoptosis through constitutive interaction with Bak.
Wang G, Barrett JW, Nazarian SH, Everett H, Gao X, Bleackley C, Colwill K, Moran MF, McFadden G. J Virol. 2004 Jul; 78(13):7097-111.
Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria. [J Virol. 2006]
Myxoma virus M11L blocks apoptosis through inhibition of conformational activation of Bax at the mitochondria.
Su J, Wang G, Barrett JW, Irvine TS, Gao X, McFadden G. J Virol. 2006 Feb; 80(3):1140-51.
Review Structural biology of the Bcl-2 family of proteins. [Biochim Biophys Acta. 2004]
Review Structural biology of the Bcl-2 family of proteins.
Petros AM, Olejniczak ET, Fesik SW. Biochim Biophys Acta. 2004 Mar 1; 1644(2-3):83-94.
Review How the Bcl-2 family of proteins interact to regulate apoptosis. [Cell Res. 2006]
Review How the Bcl-2 family of proteins interact to regulate apoptosis.
van Delft MF, Huang DC. Cell Res. 2006 Feb; 16(2):203-13.

See reviews... See all...

Cited by 24 PubMed Central articles

Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence. [PLoS Pathog. 2011]
Inhibition of apoptosis and NF-κB activation by vaccinia protein N1 occur via distinct binding surfaces and make different contributions to virulence.
Maluquer de Motes C, Cooray S, Ren H, Almeida GM, McGourty K, Bahar MW, Stuart DI, Grimes JM, Graham SC, Smith GL. PLoS Pathog. 2011 Dec; 7(12):e1002430. Epub 2011 Dec 15.
Review The essential role of evasion from cell death in cancer. [Adv Cancer Res. 2011]
Review The essential role of evasion from cell death in cancer.
Kelly GL, Strasser A. Adv Cancer Res. 2011; 111:39-96.
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa. [PLoS Pathog. 2011]
Induction of Noxa-mediated apoptosis by modified vaccinia virus Ankara depends on viral recognition by cytosolic helicases, leading to IRF-3/IFN-β-dependent induction of pro-apoptotic Noxa.
Eitz Ferrer P, Potthoff S, Kirschnek S, Gasteiger G, Kastenmüller W, Ludwig H, Paschen SA, Villunger A, Sutter G, Drexler I, et al. PLoS Pathog. 2011 Jun; 7(6):e1002083. Epub 2011 Jun 16.

See all...

Structures reported by this article

Crystal Structure Of The Myxoma Virus Anti-Apoptotic Protein M11l

PDB: 2JBX

Source: Myxoma virus

Method: X-Ray Diffraction

Resolution: 2.73 Å

See all 2 structures...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Taxonomy via GenBank
Taxonomy records associated with the current articles through taxonomic information on related molecular database records (Nucleotide, Protein, Gene, SNP, Structure).
Protein
Protein translation features of primary database (GenBank) nucleotide records reported in the current articles as well as Reference Sequences (RefSeqs) that include the articles as references.
Structure
Three-dimensional structure records in the NCBI Structure database for data reported in the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering p...
A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.
Mol Cell. 2007 Mar 23 ;25(6):933-42.

PubMed
[Primary prevention with aspirin for cardiovascular diseases in diabetic patient...
[Primary prevention with aspirin for cardiovascular diseases in diabetic patients. What evidence supports the criteria of the ADA?].
Aten Primaria. 2007 Mar ;39(3):163-4.

PubMed
[Measurement of fraction of exhaled nitric oxide with the portable NIOX-MINO mon...
[Measurement of fraction of exhaled nitric oxide with the portable NIOX-MINO monitor in healthy adults].
Arch Bronconeumol. 2007 Mar ;43(3):176-9.

PubMed
Enhancement of ATP generation capacity, antioxidant activity and immunomodulator...
Enhancement of ATP generation capacity, antioxidant activity and immunomodulatory activities by Chinese Yang and Yin tonifying herbs.
Chin Med. 2007 Mar 27 ;2:3.

PubMed
Expression of active iron regulatory factor from a full-length human cDNA by in ...
Expression of active iron regulatory factor from a full-length human cDNA by in vitro transcription/translation.
Nucleic Acids Res. 1992 Jan 11 ;20(1):33-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

A structural viral mimic of prosurvival Bcl-2: a pivotal role for sequestering proapoptotic Bax and Bak.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 24 PubMed Central articles

Structures reported by this article

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information