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Nat Struct Mol Biol. 2007 Apr;14(4):347-8. Epub 2007 Mar 25.

Mouse Piwi-interacting RNAs are 2'-O-methylated at their 3' termini.

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  • 1Department of Pathology and Laboratory Medicine, Division of Neuropathology, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA.

Abstract

Piwi-interacting RNAs (piRNAs) are a novel class of small RNAs that are expressed specifically and abundantly in male germ cells. Here we report that the 3' termini of piRNAs are 2'-O-methylated; this modification may have important implications for the biogenesis and function of piRNAs.

Comment in

  • A marked end. [Nat Struct Mol Biol. 2007]
PMID:
17384647
[PubMed - indexed for MEDLINE]
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