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Curr Opin Microbiol. 2007 Apr;10(2):169-75. Epub 2007 Mar 26.

Physiology of tmRNA: what gets tagged and why?

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  • 401 Althouse Laboratory, Penn State University, University Park, PA 16827, USA. kkeiler@psu.edu

Abstract

Transfer-messenger RNA (tmRNA) enters stalled translational complexes and, with small protein B (SmpB), mediates peptide tagging of the nascent protein and release of the stalled ribosome. Recent studies clarify how the tmRNA system is targeted to ribosomes and suggest that tmRNA-tagging is used for both quality control and specific regulation of cellular physiology.

PMID:
17383929
[PubMed - indexed for MEDLINE]
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