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J Urol. 2007 Apr;177(4):1273-5; discussion 1275-6.

The concept of lymph node density--is it ready for clinical practice?

Author information

  • 1Department of Urology, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA. herrh@mskcc.org

Abstract

PURPOSE:

The concept of lymph node density (ratio of positive-to-total number of nodes examined) is reviewed as a prognostic factor for recurrence-free survival after cystectomy in patients with invasive bladder cancer.

MATERIALS AND METHODS:

The literature was queried for all articles that directly or indirectly address lymph node density (nodal ratios) and survival of bladder cancer.

RESULTS:

Five studies on a total of 979 patients were found. In 4 studies lymph node density was a significant predictive factor for survival when adjusted for patient, tumor and treatment covariates.

CONCLUSIONS:

Considerable data support the use of lymph node density in bladder cancer prognosis. A methodological evaluation of the prognostic importance of nodal ratios in large multicenter data sets and validation in a prospective clinical trial are merited before lymph node density is accepted into routine clinical practice.

PMID:
17382708
[PubMed - indexed for MEDLINE]
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