Neurosci Lett. 2007 May 11;418(1):9-12. Epub 2007 Mar 1.

Fifty Hertz electromagnetic field exposure stimulates secretion of beta-amyloid peptide in cultured human neuroglioma.

Del Giudice E, Facchinetti F, Nofrate V, Boccaccio P, Minelli T, Dam M, Leon A, Moschini G.

Source

Research & Innovation Company, Padova, Italy.

Abstract

Recent epidemiological studies raise the possibility that individuals with occupational exposure to low frequency (50-60 Hz) electromagnetic fields (LF-EMF), are at increased risk of Alzheimer's disease (AD). However, the mechanisms through which LF-EMF may affect AD pathology are unknown. We here tested the hypothesis that the exposure to LF-EMF may affect amyloidogenic processes. We examined the effect of exposure to 3.1 mT 50 Hz LF-EMF on Abeta secretion in H4 neuroglioma cells stably overexpressing human mutant amyloid precursor protein. We found that overnight exposure to LF-EMF induces a significant increase of amyloid-beta peptide (Abeta) secretion, including the isoform Abeta 1-42, without affecting cell survival. These findings show for the first time that exposure to LF-EMF stimulates Abeta secretion in vitro, thus alluding to a potential link between LF-EMF exposure and APP processing in the brain.

PMID:: 17382472; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

Amyloid beta-Peptides

LinkOut - more resources

Full Text Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels. [Anesthesiology. 2006]
The common inhalation anesthetic isoflurane induces apoptosis and increases amyloid beta protein levels.
Xie Z, Dong Y, Maeda U, Alfille P, Culley DJ, Crosby G, Tanzi RE. Anesthesiology. 2006 May; 104(5):988-94.
Effects of 60 Hz electromagnetic field exposure on APP695 transcription levels in differentiating human neuroblastoma cells. [Bioelectrochemistry. 2002]
Effects of 60 Hz electromagnetic field exposure on APP695 transcription levels in differentiating human neuroblastoma cells.
Rao RR, Halper J, Kisaalita WS. Bioelectrochemistry. 2002 Jul; 57(1):9-15.
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695. [Neuroscience. 2007]
Huperzine A regulates amyloid precursor protein processing via protein kinase C and mitogen-activated protein kinase pathways in neuroblastoma SK-N-SH cells over-expressing wild type human amyloid precursor protein 695.
Peng Y, Lee DY, Jiang L, Ma Z, Schachter SC, Lemere CA. Neuroscience. 2007 Dec 5; 150(2):386-95. Epub 2007 Sep 14.
Review Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: possible immune cell activation. [J Cell Biochem. 2004]
Review Extremely low frequency electromagnetic fields as effectors of cellular responses in vitro: possible immune cell activation.
Simkó M, Mattsson MO. J Cell Biochem. 2004 Sep 1; 93(1):83-92.
Review Health risks of electromagnetic fields. Part I: Evaluation and assessment of electric and magnetic fields. [Crit Rev Biomed Eng. 2003]
Review Health risks of electromagnetic fields. Part I: Evaluation and assessment of electric and magnetic fields.
Habash RW, Brodsky LM, Leiss W, Krewski D, Repacholi M. Crit Rev Biomed Eng. 2003; 31(3):141-95.

See reviews... See all...

Recent activity

Clear Turn Off Turn On

Fifty Hertz electromagnetic field exposure stimulates secretion of beta-amyloid ...
Fifty Hertz electromagnetic field exposure stimulates secretion of beta-amyloid peptide in cultured human neuroglioma.
Neurosci Lett. 2007 May 11 ;418(1):9-12. Epub 2007 Mar 1 .

PubMed
Effect of low temperature and culture media on the growth and freeze-thawing tol...
Effect of low temperature and culture media on the growth and freeze-thawing tolerance of Exiguobacterium strains.
Cryobiology. 2007 Apr ;54(2):234-40. Epub 2007 Feb 6 .

PubMed
Ins and outs of dietary phytochemicals in cancer chemoprevention.
Ins and outs of dietary phytochemicals in cancer chemoprevention.
Biochem Pharmacol. 2007 Aug 15 ;74(4):533-44. Epub 2007 Feb 28 .

PubMed
Robot-assisted radical cystectomy and pelvic lymph node dissection: initial expe...
Robot-assisted radical cystectomy and pelvic lymph node dissection: initial experience at Roswell Park Cancer Institute.
Urology. 2007 Mar ;69(3):469-74.

PubMed
Nutritional and metabolic response to acute spinal-cord injury.
Nutritional and metabolic response to acute spinal-cord injury.
JPEN J Parenter Enteral Nutr. 1992 Jan-Feb ;16(1):11-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: