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J Cutan Pathol. 2007 Apr;34(4):352-4.

Skeletal muscle regeneration: report of a case presenting as a cutaneous nodule following blunt trauma to the lip.

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  • 1Department of Dermatology, Dermatopathology Section, Boston University School of Medicine, Boston, MA, USA.

Abstract

Skeletal muscle (SM) regeneration is a pleomorphic yet benign reaction pattern that follows injury to SM and has been reported to simulate histologically various malignancies such as squamous cell carcinoma and rhabdomyosarcoma. A 61-year-old man presented with a 4-month history of an enlarging nodule on the upper lip following blunt trauma. An initial punch biopsy was non-diagnostic. A deeper biopsy revealed a multilobular proliferation of atypical and pleomorphic cells with vesicular nuclei, prominent nucleoli, and large amphophilic cytoplasm. Immunoperoxidase studies showed these cells to be positive for muscle-specific actin and desmin and negative for S-100 protein and smooth muscle actin. Based on these findings, a diagnosis of skeletal muscle regeneration (SMR) was made. To our knowledge, this is the first report of SMR presenting clinically as a rapidly growing cutaneous nodule on the lip following blunt trauma.

PMID:
17381808
[PubMed - indexed for MEDLINE]
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