J Mol Biol. 1992 Jan 20;223(2):391-7.

Electron microscopy of the actin-myosin head complex in the presence of ATP.

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Department of Cell Biology, University of Massachusetts Medical School, Worcester 01655.

Abstract

The structure of the actin-myosin head complex during the ATPase cycle has been studied by electron microscopy of negatively stained acto-heavy-meromyosin. In the absence of ATP, heavy meromyosin molecules generally showed a regular, angled appearance, with both heads attached to the actin filament. In the presence of ATP, attached molecules showed a less ordered structure, often with only one head attached. We conclude that configurations other than the rigor structure occur during the actomyosin cross-bridge cycle.

PMID:: 1738154; [PubMed - indexed for MEDLINE]

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Research Support, U.S. Gov't, P.H.S.

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AR34711/AR/NIAMS NIH HHS/United States

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Cited by 14 PubMed Central articles

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