Future Oncol. 2007 Apr;3(2):149-53.

Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC.

Source

Division of Cardiothoracic Surgery, Department of Surgery, Jonsson Comprehensive Cancer Center, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. jaymoonlee@mednet.ucla.edu

Abstract

The report by Tsubochi and colleagues adds to the growing evidence indicating that tumor cyclo-oxygenase (Cox)-2 has a multifaceted role in conferring the malignant phenotype of non-small-cell lung cancer (NSCLC), and provides insight into the use of markers to provide prognostic information. Cox-2 has been implicated in apoptosis resistance, angiogenesis, decreased host immunity and enhanced invasion and metastasis, and, thus, has a critical involvement in carcinogenesis. This study, as well as others, has contributed to providing an insight into opportunities for targeted therapies in NSCLC. Cox-2 is one of the novel targets being studied for lung cancer therapy and chemoprevention.

Comment on

Ann Thorac Surg. 2006 Oct;82(4):1198-204.

PMID:: 17381414; [PubMed]

Publication Types

Comment

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Review Role of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer. [Indian J Biochem Biophys. 2007]
Review Role of cyclooxygenase-2 in tumor progression and immune regulation in lung cancer.
Patel S, Chiplunkar S. Indian J Biochem Biophys. 2007 Dec; 44(6):419-28.
Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer. [Acta Biochim Biophys Sin (Shan...]
Prognostic significance of VEGF-C expression in correlation with COX-2, lymphatic microvessel density, and clinicopathologic characteristics in human non-small cell lung cancer.
Guo X, Chen Y, Xu Z, Xu Z, Qian Y, Yu X. Acta Biochim Biophys Sin (Shanghai). 2009 Mar; 41(3):217-22.
Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer. [PLoS Med. 2007]
Aberrant DNA methylation of OLIG1, a novel prognostic factor in non-small cell lung cancer.
Brena RM, Morrison C, Liyanarachchi S, Jarjoura D, Davuluri RV, Otterson GA, Reisman D, Glaros S, Rush LJ, Plass C. PLoS Med. 2007 Mar 27; 4(3):e108.
Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells. [BMC Cancer. 2008]
Effects of COX-2 inhibition on expression of vascular endothelial growth factor and interleukin-8 in lung cancer cells.
Zhu YM, Azahri NS, Yu DC, Woll PJ. BMC Cancer. 2008 Jul 31; 8:218. Epub 2008 Jul 31.
Review Inflammation and lung carcinogenesis: applying findings in prevention and treatment. [Expert Rev Anticancer Ther. 2007]
Review Inflammation and lung carcinogenesis: applying findings in prevention and treatment.
Peebles KA, Lee JM, Mao JT, Hazra S, Reckamp KL, Krysan K, Dohadwala M, Heinrich EL, Walser TC, Cui X, et al. Expert Rev Anticancer Ther. 2007 Oct; 7(10):1405-21.

See reviews... See all...

Cited by 2 PubMed Central articles

Squamous Cell Carcinoma - Similarities and Differences among Anatomical Sites. [Am J Cancer Res. 2011]
Squamous Cell Carcinoma - Similarities and Differences among Anatomical Sites.
Yan W, Wistuba II, Emmert-Buck MR, Erickson HS. Am J Cancer Res. 2011 Jan 1; 1(3):275-300.
Review Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment. [Crit Rev Oncol Hematol. 2008]
Review Inflammation in lung carcinogenesis: new targets for lung cancer chemoprevention and treatment.
Lee JM, Yanagawa J, Peebles KA, Sharma S, Mao JT, Dubinett SM. Crit Rev Oncol Hematol. 2008 Jun; 66(3):208-17. Epub 2008 Mar 4.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevent...
Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC.
Future Oncol. 2007 Apr ;3(2):149-53.

PubMed
Management of the uninhibited bladder by selective sacral neurectomy.
Management of the uninhibited bladder by selective sacral neurectomy.
J Neurosurg. 1976 Feb ;44(2):176-85.

PubMed
MicroRNA function and mechanism: insights from zebra fish.
MicroRNA function and mechanism: insights from zebra fish.
Cold Spring Harb Symp Quant Biol. 2006 ;71:195-203.

PubMed
Novel transcribed regions in the human genome.
Novel transcribed regions in the human genome.
Cold Spring Harb Symp Quant Biol. 2006 ;71:111-6.

PubMed
Affinity of different local anesthetic drugs and catecholamines for the contralu...
Affinity of different local anesthetic drugs and catecholamines for the contraluminal transport system for organic cations in proximal tubules of rat kidneys.
J Pharmacol Exp Ther. 1992 Feb ;260(2):734-41.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Significance of cyclooxygenase-2 in prognosis, targeted therapy and chemoprevention of NSCLC.

Source

Abstract

Comment on

Publication Types

Publication Types

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information