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Structural biology of RNA silencing and its functional implications.

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  • 1Structural Biology Program, Memorial Sloan-Kettering Cancer Center, New York, New York 10021, USA.


We outline structure-function contributions from our laboratories on protein-RNA recognition events that monitor siRNA length, 5 -phosphate and 2-nucleotide 3 overhangs, as well as the architecture of Argonaute, its externally bound siRNA complex, and Argonaute-based models involving guide-strand-mediated mRNA binding, cleavage, and release.

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