Format

Send to

Choose Destination
See comment in PubMed Commons below
Exp Gerontol. 2007 Sep;42(9):845-51. Epub 2007 Feb 20.

Testing the rate-of-living/oxidative damage theory of aging in the nematode model Caenorhabditis elegans.

Author information

  • 1Biology Department, Ghent University, K.L.Ledeganckstraat 35, B-9000 Ghent, Belgium.

Abstract

The integration of the rate-of-living and oxidative damage theory of aging predicts that lifespan extension is linked to low energy metabolism, low ROS production rates, low molecular damage and a slow aging rate. In the long-lived Caenorhabditis elegans Ins/IGF-1 mutant daf-2(e1370), low carbonylation levels and postponed morphological decline comply with the latter two of these predictions. However, metabolic rates in daf-2(e1370) refute the rate-of-living theory. The apparent contradiction between increased ROS generation and long lifespan in daf-2(e1370) is reconciled by an enhanced stress defense, acknowledging oxidative damage as a probable cause of aging.

[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk