Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Toxicol Appl Pharmacol. 2007 May 1;220(3):349-56. Epub 2007 Feb 9.

Aluminum stimulates uptake of non-transferrin bound iron and transferrin bound iron in human glial cells.

Author information

  • 1Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, USA.

Abstract

Aluminum and other trivalent metals were shown to stimulate uptake of transferrin bound iron and nontransferrin bound iron in erytholeukemia and hepatoma cells. Because of the association between aluminum and Alzheimer's Disease, and findings of higher levels of iron in Alzheimer's disease brains, the effects of aluminum on iron homeostasis were examined in a human glial cell line. Aluminum stimulated dose- and time-dependent uptake of nontransferrin bound iron and iron bound to transferrin. A transporter was likely involved in the uptake of nontransferrin iron because uptake reached saturation, was temperature-dependent, and attenuated by inhibitors of protein synthesis. Interestingly, the effects of aluminum were not blocked by inhibitors of RNA synthesis. Aluminum also decreased the amount of iron bound to ferritin though it did not affect levels of divalent metal transporter 1. These results suggest that aluminum disrupts iron homeostasis in the brain by several mechanisms including the transferrin receptor, a nontransferrin iron transporter, and ferritin.

PMID:
17376497
[PubMed - indexed for MEDLINE]
PMCID:
PMC3097386
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk