Format

Send to

Choose Destination
See comment in PubMed Commons below
Biochim Biophys Acta. 2007 Apr;1768(4):1006-18. Epub 2007 Feb 20.

Cardiac GPCRs: GPCR signaling in healthy and failing hearts.

Author information

  • 1Department of Medicine, Duke University Medical Center, Durham, NC 27710, USA.

Abstract

G protein-coupled receptors (GPCRs) are widely implicated in human heart disease, making them an important target for cardiac drug therapy. The most commonly studied and clinically targeted cardiac GPCRs include the adrenergic, angiotensin, endothelin, and adenosine receptors. Treatment options focusing on the complex and integrated signaling pathways of these GPCRs are critical for the understanding and amelioration of heart disease. The focus of this review is to highlight the most commonly studied and clinically targeted cardiac GPCRs, placing emphasis on their common signaling components implicated in cardiac disease.

[PubMed - indexed for MEDLINE]
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science Icon for PubMed Central
    Loading ...
    Write to the Help Desk