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Immunity. 2007 Mar;26(3):273-5.

Tim protein structures reveal a unique face for ligand binding.

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  • 1Center for Neurologic Diseases, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02115, USA.


Tim molecules regulate T cell responses; however, the molecular basis of their ligand recognition remains largely unknown. In this issue of Immunity, Santiago et al. (2007) and Cao et al. (2007) report the crystal structures of several Tims and provide insights into the structure-function relationship of these molecules.

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