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Eur J Clin Nutr. 2008 Apr;62(4):570-4. Epub 2007 Mar 21.

Anti-inflammatory effect of virgin olive oil in stable coronary disease patients: a randomized, crossover, controlled trial.

Author information

  • 1Unitat de Lípids i Epidemiologia Cardiovascular, Institut Municipal d'Investigació Mèdica (IMIM), Barcelona, Spain. mfito@imim.es

Abstract

OBJECTIVES:

To assess the effect of two similar olive oils, but with differences in their phenolic compounds (powerful antioxidant compounds), on inflammatory markers in stable coronary heart disease patients.

DESIGN:

Placebo-controlled, crossover, randomized trial.

SETTING:

Cardiology Department of Hospital del Mar and Institut Municipal d'Investigació Mèdica (Barcelona).

SUBJECTS:

Twenty-eight stable coronary heart disease patients.

INTERVENTIONS:

A raw daily dose of 50 ml of virgin and refined olive oil (ROO) was sequentially administered over two periods of 3-weeks, preceded by 2-week washout periods in which ROO was used.

RESULTS:

Interleukin-6 (P<0.002) and C-reactive protein (P=0.024) decreased after virgin olive oil intervention. No changes were observed in soluble intercellular and vascular adhesion molecules, glucose and lipid profile.

CONCLUSIONS:

Consumption of virgin olive oil, could provide beneficial effects in stable coronary heart disease patients as an additional intervention to the pharmacological treatment.

PMID:
17375118
[PubMed - indexed for MEDLINE]
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