Format

Send to:

Choose Destination
See comment in PubMed Commons below
J Lipid Res. 2007 Jun;48(6):1253-62. Epub 2007 Mar 20.

Thematic review series: adipocyte biology. Adipose tissue function and plasticity orchestrate nutritional adaptation.

Author information

  • 1Department of Clinical Biochemistry, University of Cambridge, Cambridge, United Kingdom. jks30@cam.ac.uk

Abstract

This review focuses on adipose tissue biology and introduces the concept of adipose tissue plasticity and expandability as key determinants of obesity-associated metabolic dysregulation. This concept is fundamental to our understanding of adipose tissue as a dynamic organ at the center of nutritional adaptation. Here, we summarize the current knowledge of the mechanisms by which adipose tissue can affect peripheral energy homeostasis, particularly in the context of overnutrition. Two mechanisms emerge that provide a molecular understanding for obesity-associated insulin resistance. These are a) the dysregulation of adipose tissue expandability and b) the abnormal production of adipokines. This knowledge has the potential to pave the way for novel therapeutic concepts and strategies for managing and/or correcting complications associated with obesity and the metabolic syndrome.

PMID:
17374880
[PubMed - indexed for MEDLINE]
PMCID:
PMC4303760
Free PMC Article
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire Icon for PubMed Central
    Loading ...
    Write to the Help Desk