Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens

Seizo Sato; Jiro Takeo; Chihiro Aoyama; Hiroyuki Kawahara

doi:10.1016/j.bmc.2007.03.011

Na+-glucose cotransporter (SGLT) inhibitory flavonoids from the roots of Sophora flavescens

Bioorg Med Chem. 2007 May 15;15(10):3445-9. doi: 10.1016/j.bmc.2007.03.011. Epub 2007 Mar 12.

Authors

Seizo Sato¹, Jiro Takeo, Chihiro Aoyama, Hiroyuki Kawahara

Affiliation

¹ Central Research Laboratory, Nippon Suisan Kaisha, Ltd, 559-6 Kitano-machi, Hachioji, Tokyo 192-0906, Japan. s-satou@nissui.co.jp

PMID: 17374486
DOI: 10.1016/j.bmc.2007.03.011

Abstract

The methanol extract of Sophora flavescens, which is used in traditional Chinese medicine (sophorae radix), showed potent Na(+)-glucose cotransporter (SGLT) inhibitory activity. Our search for active components identified many well-known flavonoid antioxidants: kurarinone, sophoraflavanone G, kushenol K, and kushenol N.

MeSH terms

Animals
COS Cells
Chlorocebus aethiops
Flavonoids / isolation & purification*
Flavonoids / pharmacology*
Humans
Magnetic Resonance Spectroscopy
Mass Spectrometry
Plant Roots / chemistry
Plasmids / genetics
Reverse Transcriptase Polymerase Chain Reaction
Sodium-Glucose Transporter 1 / antagonists & inhibitors*
Sodium-Glucose Transporter 1 / genetics
Sodium-Glucose Transporter 2 / genetics
Sodium-Glucose Transporter 2 Inhibitors*
Sophora / chemistry*
Spectrometry, Mass, Electrospray Ionization

Substances

Flavonoids
SLC5A1 protein, human
SLC5A2 protein, human
Sodium-Glucose Transporter 1
Sodium-Glucose Transporter 2
Sodium-Glucose Transporter 2 Inhibitors