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Expert Opin Ther Targets. 2007 Apr;11(4):453-61.

Essential role of placental leucine aminopeptidase in gynecologic malignancy.

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  • 1Nagoya University School of Medicine, Department of Medical Science of Proteases, Nagoya, Japan.

Abstract

The M1 aminopeptidase family is important for the maturation or degradation of bioactive peptides by hydrolyzing their N-terminal amino acids. Some investigators have studied aminopeptidase in the maintenance of homeostasis including maintenance of normal pregnancy, memory retention, blood pressure regulation and antigen presentation. However, there are a few reports on the relation between the M1 aminopeptidase family and carcinoma. In addition to its capacity to degrade a range of peptides, placental-leucine aminopeptidase (P-LAP) has novel functions that impact on normal cells and neoplastic cells. P-LAP is the focus of this review.

PMID:
17373876
[PubMed - indexed for MEDLINE]
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