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1: ACS Chem Biol. 2007 Mar 20;2(3):155-8.Click here to read Links

Telomerase unplugged.

Cristofari G, Sikora K, Lingner J.

Swiss Institute for Experimental Cancer Research, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland.

The control of telomerase activity at chromosome ends by telomere-binding proteins is critical for telomere length homeostasis. Two recent papers identify TPP1 as a critical mediator of this control. TPP1 forms part of the telomeric shelterin complex while also associating with telomerase, stimulating its activity and processivity.

PMID: 17373762 [PubMed - indexed for MEDLINE]

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