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Mov Disord. 2007 Apr 15;22(5):720-2.

Malignant melanoma in early Parkinson's disease: the DATATOP trial.

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  • 1Department of Neurology, University of Rochester Medical Center, Rochester, NY 14620, USA.


The available epidemiological data on the incidence of malignant melanoma in Parkinson's disease are contradictory. The role of levodopa therapy in this context has been debated. We identified all known cases of malignant melanoma (N = 5) in the DATATOP clinical trial cohort and compared that to published expected values (N = 1.5) for a standard healthy population. The standardized event ratio was 3.3 (95% confidence interval, 1.1-7.8), indicating that incidence of malignant melanoma was higher than expected. We found no association between levodopa therapy and the incidence of melanoma.

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