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1: Bioessays. 2007 Apr;29(4):356-70.Click here to read Click here to read Links

GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in vivo.

Bustelo XR, Sauzeau V, Berenjeno IM.

Centro de Investigación del Cáncer and Instituto de Biología Molecular y Celular del Cáncer (IBMCC), CSIC-University of Salamanca, Salamanca, Spain. xbustelo@usal.es

Rho/Rac proteins constitute a subgroup of the Ras superfamily of GTP hydrolases. Although originally implicated in the control of cytoskeletal events, it is currently known that these GTPases coordinate diverse cellular functions, including cell polarity, vesicular trafficking, the cell cycle and transcriptomal dynamics. In this review, we will provide an overview on the recent advances in this field regarding the mechanism of regulation and signaling, and the roles in vivo of this important GTPase family. (c) 2007 Wiley Periodicals, Inc.

PMID: 17373658 [PubMed - indexed for MEDLINE]

PMCID: PMC1971132