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Antimicrob Agents Chemother. 2007 Jun;51(6):2226-9. Epub 2007 Mar 19.

Treatment of Staphylococcus aureus biofilm infection by the quorum-sensing inhibitor RIP.

Author information

  • 1Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, 200 Westboro Road, North Grafton, MA 01536, USA. naomi.balaban@tufts.edu

Abstract

The quorum-sensing inhibitor RIP inhibits staphylococcal TRAP/agr systems and both TRAP- and agr-negative strains are deficient in biofilm formation in vivo, indicating the importance of quorum sensing to biofilms in the host. RIP injected systemically into rats has been found to have strong activity in preventing methicillin-resistant Staphylococcus aureus graft infections, suggesting that RIP can be used as a therapeutic agent.

PMID:
17371825
[PubMed - indexed for MEDLINE]
PMCID:
PMC1891383
Free PMC Article
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