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Int J Gynaecol Obstet. 2007 May;97(2):115-9. Epub 2007 Mar 21.

Maternal serum corticotropin-releasing hormone and ACTH levels as predictive markers of premature labor.

Author information

  • 1Laboratory of Human Reproduction, Department of Obstetrics & Gynecology, Medical School, University of Crete, Heraklion, Greece. makrigia@med.uoc.gr

Abstract

OBJECTIVE:

To investigate whether corticotropin-releasing hormone (CRH) and corticotropin (ACTH) plasma concentrations in women diagnosed with preterm labor are of potential clinical value in the assessment of the risk of preterm birth.

METHOD:

Plasma samples of 79 women diagnosed with preterm labor were used in this study. Samples were divided into three groups based on the week of gestation (24th-28th, 29th-32nd, 33rd-37th). CRH and ACTH values were determined by ELISA.

RESULT:

Mean maternal peripheral plasma values of CRH and ACTH were significantly higher (p<0.001) in women who were initially diagnosed with preterm labor and finally delivered a preterm birth, compared to women with the same diagnosis but with term birth.

CONCLUSION:

CRH and ACTH serum levels in women diagnosed with preterm labor could be used as predictors for the timing of parturition.

PMID:
17368647
[PubMed - indexed for MEDLINE]
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