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Psychiatr Clin North Am. 2007 Mar;30(1):13-29.

A critical overview of the pharmacologic management of treatment-resistant depression.

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  • 1Depression Clinical and Research Program, Massachusetts General Hospital, 50 Staniford Street, Boston, MA 02114, USA. anierenberg@partners.org


Major depressive disorder is a frequent, serious disorder that usually responds partially to treatment and leaves many patients with treatment resistance. This article reviews and critically evaluates the evidence for the management of treatment-resistant depression and examines pharmacologic approaches to alleviate the suffering of patients who benefit insufficiently from initial treatment.

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