Neurology. 1992 Feb;42(2):367-70.

Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion.

Weller M, Liedtke W, Petersen D, Opitz H, Poremba M.

Source

Department of Neurology, University of Tübingen, Germany.

Abstract

We report the clinical history, neuroradiology, and autopsy findings in a patient with very late onset, at age 57, of adrenoleukodystrophy (ALD) presenting with dementia, hemianopia, and gait apraxia. Open brain biopsy, elevated plasma very-long-chain fatty acids, and autopsy confirmed the diagnosis of ALD. Demyelinative lesions were most extensive at the site of a recent cerebral contusion. CNS trauma may have precipitated or accelerated demyelination in this patient carrying the ALD gene.

PMID:: 1736167; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

Fatty Acids

LinkOut - more resources

Full Text Sources

Ovid Technologies, Inc.

Other Literature Sources

COS Scholar Universe

Medical

Supplemental Content

Save items

Related citations in PubMed

Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy. [Arch Neurol. 2007]
Magnetic resonance imaging detection of lesion progression in adult patients with X-linked adrenoleukodystrophy.
Eichler F, Mahmood A, Loes D, Bezman L, Lin D, Moser HW, Raymond GV. Arch Neurol. 2007 May; 64(5):659-64.
Acute onset of X-linked adrenoleukodystrophy mimicking encephalitis. [Brain Dev. 1994]
Acute onset of X-linked adrenoleukodystrophy mimicking encephalitis.
Zammarchi E, Donati MA, Tucci F, Fonda C, Fanelli F, Pazzaglia R. Brain Dev. 1994 May-Jun; 16(3):238-40.
Cerebral adrenoleukodystrophy (ALD) in only one of monozygotic twins with an identical ALD genotype. [Ann Neurol. 1996]
Cerebral adrenoleukodystrophy (ALD) in only one of monozygotic twins with an identical ALD genotype.
Korenke GC, Fuchs S, Krasemann E, Doerr HG, Wilichowski E, Hunneman DH, Hanefeld F. Ann Neurol. 1996 Aug; 40(2):254-7.
Review Cerebral inflammation in X-linked adrenoleukodystrophy. [Arch Immunol Ther Exp (Warsz)....]
Review Cerebral inflammation in X-linked adrenoleukodystrophy.
McGuinness MC, Smith KD. Arch Immunol Ther Exp (Warsz). 1999; 47(5):281-7.
Review Therapy of X-linked adrenoleukodystrophy. [Expert Rev Neurother. 2008]
Review Therapy of X-linked adrenoleukodystrophy.
Semmler A, Köhler W, Jung HH, Weller M, Linnebank M. Expert Rev Neurother. 2008 Sep; 8(9):1367-79.

See reviews... See all...

Cited by 3 PubMed Central articles

Spinal cord trauma and the molecular point of no return. [Mol Neurodegener. 2012]
Spinal cord trauma and the molecular point of no return.
Yip PK, Malaspina A. Mol Neurodegener. 2012 Feb 8; 7:6. Epub 2012 Feb 8.
Review Current and future pharmacological treatment strategies in X-linked adrenoleukodystrophy. [Brain Pathol. 2010]
Review Current and future pharmacological treatment strategies in X-linked adrenoleukodystrophy.
Berger J, Pujol A, Aubourg P, Forss-Petter S. Brain Pathol. 2010 Jul; 20(4):845-56.
Review X linked adrenoleukodystrophy: clinical presentation, diagnosis, and therapy. [J Neurol Neurosurg Psychiatry....]
Review X linked adrenoleukodystrophy: clinical presentation, diagnosis, and therapy.
van Geel BM, Assies J, Wanders RJ, Barth PG. J Neurol Neurosurg Psychiatry. 1997 Jul; 63(1):4-14.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by...
Very-late-onset adrenoleukodystrophy: possible precipitation of demyelination by cerebral contusion.
Neurology. 1992 Feb ;42(2):367-70.

PubMed
The international growth standard for children and adolescents project: environm...
The international growth standard for children and adolescents project: environmental influences on preadolescent and adolescent growth in weight and height.
Food Nutr Bull. 2006 Dec ;27(4 Suppl Growth Standard):S279-94.

PubMed
Fatal familial insomnia: clinical and pathologic study of five new cases.
Fatal familial insomnia: clinical and pathologic study of five new cases.
Neurology. 1992 Feb ;42(2):312-9.

PubMed
Is the Central Valley of Costa Rica a genetic isolate?
Is the Central Valley of Costa Rica a genetic isolate?
Rev Biol Trop. 2004 Sep ;52(3):629-44.

PubMed
Contrast-enhanced MR imaging in patients with BI-RADS 3-5 microcalcifications.
Contrast-enhanced MR imaging in patients with BI-RADS 3-5 microcalcifications.
Radiol Med. 2007 Mar ;112(2):272-86. Epub 2007 Mar 19 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: