Nature. 2007 Mar 15;446(7133):284-7.

The molecular choreography of a store-operated calcium channel.

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Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, California 94305, USA. rslewis@stanford.edu

Abstract

Store-operated calcium channels (SOCs) serve essential functions from secretion and motility to gene expression and cell growth. A fundamental mystery is how the depletion of Ca2+ from the endoplasmic reticulum (ER) activates Ca2+ entry through SOCs in the plasma membrane. Recent studies using genetic approaches have identified genes encoding the ER Ca2+ sensor and a prototypic SOC, the Ca2+-release-activated Ca2+ (CRAC) channel. New findings reveal a unique mechanism for channel activation, in which the CRAC channel and its sensor migrate independently to closely apposed sites of interaction in the ER and the plasma membrane.

PMID:: 17361175; [PubMed - indexed for MEDLINE]

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