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Proc Natl Acad Sci U S A. 2007 Mar 6;104(10):3865-70. Epub 2007 Feb 28.

DMY gene induces male development in genetically female (XX) medaka fish.

Author information

  • 1Precursory Research for Embryonic Science and Technology (PRESTO), Japan Science and Technology Agency, Kawaguchi 332-0012, Japan.

Erratum in

  • Proc Natl Acad Sci U S A. 2007 May 1;104(18):7729.

Abstract

Although the sex-determining gene SRY/Sry has been identified in mammals, homologues and genes that have a similar function have yet to be identified in nonmammalian vertebrates. Recently, DMY (the DM-domain gene on the Y chromosome) was cloned from the sex-determining region on the Y chromosome of the teleost fish medaka (Oryzias latipes). DMY has been shown to be required for the normal development of male individuals. In this study, we show that a 117-kb genomic DNA fragment that carries DMY is able to induce testis differentiation and subsequent male development in XX (genetically female) medaka. In addition, overexpression of DMY cDNA under the control of the CMV promoter also caused XX sex reversal. These results demonstrate that DMY is sufficient for male development in medaka and suggest that the functional difference between the X and Y chromosomes in medaka is a single gene. Our data indicate that DMY is an additional sex-determining gene in vertebrates.

PMID:
17360444
[PubMed - indexed for MEDLINE]
PMCID:
PMC1820675
Free PMC Article

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