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1: J Vet Med A Physiol Pathol Clin Med. 2007 Feb;54(1):48-50.Click here to read Links

Pharmacokinetics of intramuscular ketamine in young ostriches premedicated with romifidine.

De Lucas JJ, Rodríguez C, Marín M, González F, Ballesteros C, San Andrés MI.

Cátedra de Farmacología, Farmacia y Terapéutica, Facultad de Veterinaria, Universidad Complutense de Madrid, Avda/Puerta de Hierro s.n., 28040 Madrid, Spain.

Ketamine is a short-acting dissociative anaesthetic for chemical restraint and surgical anaesthesia in domestic and non-domestic animals. The present study was designed to determine the pharmacokinetics of a single dose of ketamine (10 mg/kg) after intramuscular (i.m.) administration to young ostriches premedicated with romifidine. Ketamine was rapidly absorbed after i.m. administration. Maximal ketamine concentration (C(max)) of 2.93 +/- 0.61 microg/ml was reached at 12.5 +/- 2.50 min and thereafter ketamine concentrations decreased rapidly. The elimination half-life (t(1/2 z)) obtained was 62.37 +/- 17.37 min and mean residence time (MRT) was 77.33 +/- 19.12 min. The area under the curve (AUC) was 114.19 +/- 15.76 microg x min/ml.

PMID: 17359455 [PubMed - indexed for MEDLINE]