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Nat Rev Mol Cell Biol. 2007 Apr;8(4):319-30. Epub 2007 Mar 14.

The folding and evolution of multidomain proteins.

Author information

  • 1MRC Laboratory of Molecular Biology, Hills Road, Cambridge CB2 2QH, UK.


Analyses of genomes show that more than 70% of eukaryotic proteins are composed of multiple domains. However, most studies of protein folding focus on individual domains and do not consider how interactions between domains might affect folding. Here, we address this by analysing the three-dimensional structures of multidomain proteins that have been characterized experimentally and observe that where the interface is small and loosely packed, or unstructured, the folding of the domains is independent. Furthermore, recent studies indicate that multidomain proteins have evolved mechanisms to minimize the problems of interdomain misfolding.

[PubMed - indexed for MEDLINE]
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