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J Comb Chem. 2007 May-Jun;9(3):513-9. Epub 2007 Mar 13.

Selenium-based safety-catch linker: solid-phase synthesis of vinyl-substituted oxadiazoles and triazoles.

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  • 1Department of Chemistry, Zhejiang University (XixiCampus), Hangzhou 310028, PR China.

Abstract

Vinyl-substituted oxadiazoles and triazoles were prepared through hydrazinolysis, acylation, cyclocondensation, and elimination of selenium resins. The polystyrene-supported resins used here not only facilitate separation of products but also serve as a pro-vinyl safety-catch linker.

PMID:
17352499
[PubMed - indexed for MEDLINE]
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