Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Nutrition. 2007 Apr;23(4):292-5. Epub 2007 Mar 13.

New insights about iron bioavailability inhibition by zinc.

Author information

  • 1Institute of Nutrition and Food Technology, University of Chile, Santiago, Chile. molivare@inta.cl <molivare@inta.cl>

Abstract

OBJECTIVE:

We measured the effects of lower and higher doses of zinc (Zn) given as an aqueous solution on the bioavailability of iron (Fe).

METHODS:

Fourteen healthy subjects received a solution with 0.5 mg of elemental Fe as ferrous sulfate given alone or with 0.59 mg of Zn as zinc sulfate (molar ratio Zn:Fe 1:1). Fourteen days after they received a second solution with 10 mg of Fe given alone or with 11.71 mg of Zn (molar ratio Zn:Fe 1:1). Iron bioavailability was assessed by erythrocyte incorporation of iron radioisotopes (55)Fe and (59)Fe.

RESULTS:

No significant effect of Zn on Fe bioavailability was observed at lower doses; however, at higher doses Fe bioavailability was inhibited by 56% (P < 0.001, repeated measures analysis of variance).

CONCLUSION:

The inhibitory effect of Zn on Fe bioavailability depends on the total amount of both minerals present in the intestinal lumen. This fact should be considered when designing a supplementation program if Fe and Zn are to be provided together.

PMID:
17350802
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk