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    FEBS Lett. 2007 Apr 3;581(7):1397-402. Epub 2007 Mar 5.

    PKCzetaII is a target for degradation through the tumour suppressor protein pVHL.

    Iturrioz X, Parker PJ.

    Source

    Protein Phosphorylation Laboratory, Cancer Research UK, London Research Institute, 44 Lincoln's Inn Fields Laboratories, London WC2A 3PX, UK.

    Abstract

    PKCzetaII is a rapidly degraded variant of PKCzeta that suppresses epithelial cell polarisation. It is shown here that PKCzetaII is a target for the E3 ligase and tumour suppressor Von Hippel-Lindau protein (pVHL). Deletion studies demonstrate that the C-terminal region is required for the pVHL and proteasome dependent turnover of PKCzetaII, however it is the N-terminal PB1 domain of PKCzetaII that is required for pVHL complex formation. Reciprocal deletion studies define the pVHL effector domain as the dominant PKCzetaII binding site. The results indicate that pVHL recruits PKCzetaII via its PB1 domain and causes ubiquitination and degradation via the distal C-terminus of PKCzetaII.

    PMID:
    17350623
    [PubMed - indexed for MEDLINE]

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