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Am J Obstet Gynecol. 2007 Mar;196(3):229.e1-4.

Chorioamnionitis and fetal response in stillbirth.

Author information

  • 1Department of Neonatal Medicine, Royal Prince Alfred Hospital, Camperdown, New South Wales, Australia.

Abstract

OBJECTIVE:

The purpose of this study was to determine the incidence of chorioamnionitis and fetal inflammatory response in a stillborn cohort and the relationship of fetal response to spontaneous labor, unexplained antepartum death, and spontaneous preterm death.

STUDY DESIGN:

In a 15-year hospital cohort study, placental histopathologic evidence, labor onset, gestation, and cause of death classification data were analyzed.

RESULTS:

Of 459 stillbirths, 428 stillbirths were included. The incidence of chorioamnionitis was 36.9%, with higher rates evident in early and late gestation. A fetal inflammatory response was present in 13.3% and correlated with spontaneous labor and very early spontaneous preterm death. The absence of a fetal response was associated with unexplained antepartum death.

CONCLUSION:

The increased incidence of chorioamnionitis at extremes of gestation in stillbirth is novel and has important implications. The impact of a fetal response is gestation dependent and its absence is associated with unexplained antepartum death.

PMID:
17346531
[PubMed - indexed for MEDLINE]
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