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Int Psychogeriatr. 2007 Aug;19(4):757-66. Epub 2007 Mar 9.

White matter microstructural abnormalities in late-life depression.

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  • 1Department of Radiology, Peking University People's Hospital, Beijing, China.

Abstract

OBJECTIVE:

To evaluate the location and the degree of white matter damage in late-life depression using diffusion tensor imaging (DTI).

METHODS:

Thirty-one patients with late-life depression and 15 healthy volunteers matched for age, gender and years of education received conventional MRI (magnetic resonance imaging) and MR-diffusion tensor scanning. The fractional anisotropy (FA) values of white matter were measured respectively in frontal and temporal regions and the corpus callosum.

RESULTS:

FA values were significantly decreased in the frontal (superior and middle frontal gyrus), and temporal (right parahippocampal gyrus) regions of elderly patients with depression compared with healthy controls.

CONCLUSION:

Microstructural changes in the frontal (superior and middle frontal gyrus) and temporal (right parahippocampal gyrus) areas are associated with late-life depression.

PMID:
17346365
[PubMed - indexed for MEDLINE]
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