Display Settings:

Format

Send to:

Choose Destination
We are sorry, but NCBI web applications do not support your browser and may not function properly. More information
J Neurol. 2007 Mar;254(3):327-32. Epub 2007 Mar 7.

Neurological and functional recovery in human stroke are associated with peripheral blood CD34+ cell mobilization.

Author information

  • 1Department of Neurology (Stroke Unit), University Hospital Pasteur, 30 avenue de la voie Romaine, Nice Cedex, BP69, 06002, France. dunac.a@chu-nice.fr

Abstract

BACKGROUND:

A spontaneous mobilization of Peripheral Blood-Mononuclear CD34+ Cells (PB-MNC-CD34+) has recently been reported in human myocardial infarction and found to be related to improved heart function and survival. However, nothing is known regarding a possible relation between PB-MNC-CD34+ mobilization and neurological recovery in human acute cerebral ischemia.

METHODS AND RESULTS:

PB-MNC-CD34+ were determined daily after an acute cerebral ischemic attack for 14 days in 25 patients with acute ischemic stroke and compared with controls. Results indicated that stroke was followed by large and bursting mobilizations of PB-MNC-CD34+. The amplitude of the mobilizations was similar to those observed in Granulocyte Colony Stimulating Factor (G-CSF) conditioned aplastic patients following myeloablative therapy before leukapheresis and autologous bone graft. The extent of PB-MNC-CD34+ mobilization in each patient was directly related to neurological and functional recoveries as assessed by NIH Stroke Scale, and modified Rankin Scale respectively.

CONCLUSIONS:

The mobilization of PB-MNC-CD34+ cells might be predictive of neurological and functional recovery.

PMID:
17345048
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for Springer
    Loading ...
    Write to the Help Desk