Antimicrob Agents Chemother. 2007 May;51(5):1852-4. Epub 2007 Mar 5.

Artemisinins inhibit Trypanosoma cruzi and Trypanosoma brucei rhodesiense in vitro growth.

Mishina YV, Krishna S, Haynes RK, Meade JC.

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Department of Microbiology, University of Mississippi Medical Center, Jackson, MI 39216, USA.

Abstract

Artemisinin compounds inhibit in vitro growth of cultured Trypanosoma cruzi and Trypanosoma brucei rhodesiense at concentrations in the low micromolar range. Artemisinin also inhibits calcium-dependent ATPase activity in T. cruzi membranes, suggesting a mode of action via membrane pumps. Artemisinins merit further investigation as chemotherapeutic options for these pathogens.

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PMCID:: PMC1855540

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