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Bioorg Med Chem. 2007 May 1;15(9):3143-51. Epub 2007 Feb 22.

Further studies on the effect of lysine at the C-terminus of the Dmt-Tic opioid pharmacophore.

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  • 1Department of Toxicology, University of Cagliari, I-09124 Cagliari, Italy. gbalboni@unica.it <gbalboni@unica.it>

Abstract

A wide range of activities are induced by Lys when introduced at C-terminus of the delta-opioid Dmt-Tic pharmacophore through the alpha-amine group, including: improved delta-antagonism, mu-agonism and mu-antagonism. Here we report the synthesis of a new series of compounds with the general formula H-Dmt-Tic-NH-(CH(2))(4)-CH(R)-R' (R=-NH(2), -NH-Ac, -NH-Z; R'=CO-NH-Ph, -CO-NH-CH(2)-Ph, -Bid) in which Lys is linked to Dmt-Tic through its side-chain amine group. All new compounds (1-9) displayed potent and selective delta-antagonism (MVD, pA(2)=7.81-8.27), which was independent of the functionalized alpha-amine and carboxylic groups of C-terminal Lys. This behaviour suggests a direct application as a prototype intermediate, such as Boc-Dmt-Tic-epsilon-Lys(Z)-OMe, which could be successfully applied in the synthesis (after Z or methyl ester removal) of unique designed multiple ligands containing the pharmacophore of the quintessential delta-antagonist Dmt-Tic and another opioid or biologically active non-opioid ligand.

PMID:
17339114
[PubMed - indexed for MEDLINE]
PMCID:
PMC2377021
Free PMC Article
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