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1: J Bacteriol. 2007 May;189(9):3639-44. Epub 2007 Mar 2.Click here to read Click here to read Links

A putative gene cluster for aminoarabinose biosynthesis is essential for Burkholderia cenocepacia viability.

Ortega XP, Cardona ST, Brown AR, Loutet SA, Flannagan RS, Campopiano DJ, Govan JR, Valvano MA.

Department of Microbiology and Immunology, Infectious Diseases Research Group, Siebens-Drake Medical Research Institute, University of Western Ontario, London, Ontario, Canada.

Using a conditional mutagenesis strategy we demonstrate here that a gene cluster encoding putative aminoarabinose (Ara4N) biosynthesis enzymes is essential for the viability of Burkholderia cenocepacia. Loss of viability is associated with dramatic changes in bacterial cell morphology and ultrastructure, increased permeability to propidium iodide, and sensitivity to sodium dodecyl sulfate, suggesting a general cell envelope defect caused by the lack of Ara4N.

PMID: 17337576 [PubMed - indexed for MEDLINE]

PMCID: PMC1855895