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Biol Psychiatry. 2007 Aug 1;62(3):270-3. Epub 2007 Mar 6.

Resting state cortical connectivity reflected in EEG coherence in individuals with autism.

Author information

  • 1University of Washington Autism Center, Seattle, Washington 98195, USA. mmurias@u.washington.edu

Abstract

BACKGROUND:

Theoretical conceptions of autism spectrum disorder (ASD) and experimental studies of cerebral blood flow suggest abnormalities in connections among distributed neural systems in ASD.

METHODS:

Functional connectivity was assessed with electroencephalographic coherence between pairs of electrodes in a high-density electrode array in narrow frequency bands among 18 adults with ASD and 18 control adults in an eyes closed resting state.

RESULTS:

In the theta (3-6 Hz) frequency range, locally elevated coherence was evident for the ASD group, especially within left hemisphere frontal and temporal regions. In the lower alpha range (8-10 Hz), globally reduced coherence was evident for the ASD group within frontal regions and between frontal and all other scalp regions. The ASD group exhibited significantly greater relative power between 3 and 6 Hz and 13-17 Hz and significantly less relative power between 9 and 10 Hz.

CONCLUSIONS:

Robust patterns of over- and under-connectivity are apparent at distinct spatial and temporal scales in ASD subjects in the eyes closed resting state.

PMID:
17336944
[PubMed - indexed for MEDLINE]
PMCID:
PMC2001237
Free PMC Article

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