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    Nat Chem Biol. 2007 Apr;3(4):211-2. Epub 2007 Mar 4.

    Discovery of a natural thiamine adenine nucleotide.

    Bettendorff L, Wirtzfeld B, Makarchikov AF, Mazzucchelli G, Frédérich M, Gigliobianco T, Gangolf M, De Pauw E, Angenot L, Wins P.

    Source

    Center for Cellular and Molecular Neurobiology, University of Liège, Avenue de l'Hôpital 1, B-4000 Liège, Belgium. l.bettendorff@ulg.ac.be

    Abstract

    Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.

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    PMID:
    17334376
    [PubMed - indexed for MEDLINE]

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