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1: Nat Chem Biol. 2007 Apr;3(4):211-2. Epub 2007 Mar 4. Links
Comment in:
Nat Chem Biol. 2007 Apr;3(4):202-3.

Discovery of a natural thiamine adenine nucleotide.

Bettendorff L, Wirtzfeld B, Makarchikov AF, Mazzucchelli G, Frédérich M, Gigliobianco T, Gangolf M, De Pauw E, Angenot L, Wins P.

Center for Cellular and Molecular Neurobiology, University of Liège, Avenue de l'Hôpital 1, B-4000 Liège, Belgium. l.bettendorff@ulg.ac.be

Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.

PMID: 17334376 [PubMed - indexed for MEDLINE]

Patient Drug Information

  • Thiamine

    Thiamine is a vitamin used by the body to break down sugars in the diet. The medication helps correct nerve and heart problems that occur when a person's diet does not contain enough thiamine.

  • Source: AHFS Consumer Medication Information