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Nat Chem Biol. 2007 Apr;3(4):211-2. Epub 2007 Mar 4.

Discovery of a natural thiamine adenine nucleotide.

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  • 1Center for Cellular and Molecular Neurobiology, University of Liège, Avenue de l'Hôpital 1, B-4000 Liège, Belgium.


Several important cofactors are adenine nucleotides with a vitamin as the catalytic moiety. Here, we report the discovery of the first adenine nucleotide containing vitamin B1: adenosine thiamine triphosphate (AThTP, 1), or thiaminylated ATP. We discovered AThTP in Escherichia coli and found that it accumulates specifically in response to carbon starvation, thereby acting as a signal rather than a cofactor. We detected smaller amounts in yeast and in plant and animal tissues.

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