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1: Cancer Metastasis Rev. 2007 Mar;26(1):141-52.Click here to read Links

The folate receptor: what does it promise in tissue-targeted therapeutics?

Salazar MD, Ratnam M.

Department of Biochemistry and Cancer Biology, Medical University of Ohio, Toledo, OH 43614, USA. mdalincourt@meduohio.edu

For over a decade the folate receptor has been intensively investigated as a means for tumor-specific delivery of a broad range of experimental therapies including several conceptually new treatments. Despite a few set backs in clinical trials, the literature is replete with encouraging in vitro and pre-clinical studies of gynecological and other tumors and more therapeutic approaches are ready for clinical testing. Recent studies have added myelogenous leukemias to the list of candidate cancers for FR-targeted therapies. Each approach faces unique challenges in translation that could be addressed through a mechanistic understanding of the function and expression of the receptor in the appropriate experimental systems and by improvements in the technology. This review discusses FR in the context of positive recent developments in broad areas of FR-targeted therapy and attempts to highlight its potential and the anticipated challenges.

PMID: 17333345 [PubMed - indexed for MEDLINE]

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  • Folic Acid (Folvite® )

    Folic acid is used to treat or prevent folic acid deficiency. It is a B-complex vitamin needed by the body to manufacture red blood cells. A deficiency of this vitamin causes certain types of anemia (low red blood cell c...

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