Trends Microbiol. 2007 Apr;15(4):147-9. Epub 2007 Feb 28.

Another brick in the wall.

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Department of Microbiology and Immunology, University of Rochester Medical Center, 601 Elmwood Ave, Box 672, Rochester, NY 14642, USA. martin_pavelka@urmc.rochester.edu

Abstract

The existence of a peptidoglycan cell wall in chlamydiae has been debated for several years. Several studies suggest that these organisms synthesize a cell wall, but some of the components and biosynthetic machinery seem to be missing and a bona fide cell wall has yet to be described. A recent study has revealed that a functional pathway for meso-diaminopimelate, one of the missing bricks for the wall, exists in chlamydiae. Here, I review the chlamydial cell wall paradox and discuss the importance of this new finding.

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